Article
Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2009
Thiel Steffen, Kolev Martin, Degn Søren, Steffensen Rudi, Hansen Annette G, Ruseva Marieta, Jensenius Jens C
Abstract excerpt
Mannan-binding lectin-associated serine protease 2 (MASP-2) is an enzyme of the innate immune system. MASP-2 forms complexes with the pattern recognition molecules mannan-binding lectin (MBL), H-ficolin, L-ficolin, or M-ficolin, and is activated when one of these proteins recognizes microorganisms and subsequently cleaves complement factors C4 and C2, thus initiating the activation of the complement system....
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