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Article

Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer.

Scandinavian journal of immunology - 1 Feb 2011

Ytting H, Christensen I J, Steffensen R, Alsner J, Thiel S, Jensenius J C, Hansen U, Nielsen H J

Abstract excerpt

Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2. In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict...

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Identifiers

PMID: 21198752
DOI: 10.1111/j.1365-3083.2010.02480.x

Genes

MBL2

Variants

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