Article
Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults.
The Journal of allergy and clinical immunology - 1 Aug 2008
Garcia-Laorden M Isabel, Sole-Violan Jordi, Rodriguez de Castro Felipe, Aspa Javier, Briones M Luisa, Garcia-Saavedra Ayoze, Rajas Olga, Blanquer Jose, Caballero-Hidalgo Araceli, Marcos-Ramos J Alberto, Hernandez-Lopez Javier, Rodriguez-Gallego Carlos
Abstract excerpt
BACKGROUND: Community-acquired pneumonia (CAP) is the leading cause of death from infection in developed countries. Mannose-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) deficiencies are common primary immunodeficiencies the clinical penetrance of which remains controversial. MBL is a serum lectin that mediates phagocytosis and activates the lectin pathway of complement involving MASP-2....
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