Article
Mannose-binding lectin deficiency and respiratory tract infection.
Journal of innate immunity - 1 Jan 2010
Eisen Damon P
Abstract excerpt
Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that kills a wide range of pathogenic microbes through complement activation. A substantial proportion of all human populations studied to date have MBL deficiency due to MBL2 polymorphisms, which potentially increases susceptibility to infectious disease. MBL binds numerous respiratory pathogens but the capsule of Streptococcus...
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