Analysis of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human lymphoblastoid cells.

doi:10.1093/carcin/16.4.713

Back to search

Article

Analysis of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human lymphoblastoid cells.

Carcinogenesis - 1 Apr 1995

Morgenthaler P M, Holzhäuser D

Abstract excerpt

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic aromatic amine that is formed in abundance in cooked meats, has been found to be mutagenic in human lymphoblastoid TK6 cells at the thymidine kinase and hypoxanthine-guanine phosphoribosyl transferase (hgprt) loci. The mutatio...

Topics

Base Sequence
Cell Survival
Cells, Cultured
DNA Mutational Analysis
Humans
Imidazoles
Lymphocytes
Molecular Sequence Data
Mutagens
Mutation
Sensitivity and Specificity

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.