Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Determination of point mutational spectra of benzo[a]pyrene-diol epoxide in human cells.

Environmental health perspectives - 1 Nov 1992

Keohavong P, Thilly W G

Abstract excerpt

The primary goal of our research consists of developing means sufficiently sensitive to allow assessment of human exposure to environmental carcinogens. We describe here a new approach for analyzing point mutational spectra and a test for its validity and precision using cultured human cells exposed to high doses of environmental carcinogens. The approach in its present form includes a) treatment of independent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to DNA Mutational Analysis
Share to Electrophoresis, Agar Gel

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Polymerase Chain Reaction

Share to Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 1486852
DOI: 10.1289/ehp.9298215
PMCID: PMC1519600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Determination of point mutational spectra of benzo[a]pyrene-diol epoxide in human cells.PMID 1486852Read ↗

Determination of Mutational Spectra Induced by Environmental Toxicants in Complex Human Cell Populations.Semantic proximity Read ↗

Analysis of point mutations induced by ultraviolet light in human cells.Semantic proximity Read ↗

Kinds and location of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in diploid human fibroblasts.Semantic proximity Read ↗

Analysis of hprt mutations occurring in human TK6 lymphoblastoid cells following exposure to 1,2,3,4-diepoxybutane.Semantic proximity Read ↗

Strand specificity for mutations induced by (+)-anti BPDE in the hprt gene in human T-lymphocytes.Semantic proximity Read ↗

Quantification and molecular characterization of hprt mutants of human T-lymphocytes.Semantic proximity Read ↗

Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzo[a]pyrene trans-7,8- diol-anti-9,10-epoxide.Semantic proximity Read ↗

Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection.Semantic proximity Read ↗

Molecular analysis of ultraviolet-induced mutations in a xeroderma pigmentosum cell line.Semantic proximity Read ↗

Mutagenic selectivity at the HPRT locus in V-79 cells: comparison of mutations caused by bay-region benzo[a]pyrene 7,8-diol-9,-10-epoxide enantiomers with high and low carcinogenic activity.Semantic proximity Read ↗

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.Semantic proximity Read ↗

The genome as a record of environmental exposure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.