Article
Determination of point mutational spectra of benzo[a]pyrene-diol epoxide in human cells.
Environmental health perspectives - 1 Nov 1992
Keohavong P, Thilly W G
Abstract excerpt
The primary goal of our research consists of developing means sufficiently sensitive to allow assessment of human exposure to environmental carcinogens. We describe here a new approach for analyzing point mutational spectra and a test for its validity and precision using cultured human cells exposed to high doses of environmental carcinogens. The approach in its present form includes a) treatment of independent...
Topics
- Benzopyrenes
- Cells, Cultured
- DNA Mutational Analysis
- Electrophoresis, Agar Gel
- Humans
- Mutation
- Polymerase Chain Reaction
- Sensitivity and Specificity