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Article

Promoter variant of PIK3C3 is associated with autoimmunity against Ro and Sm epitopes in African-American lupus patients.

Journal of biomedicine & biotechnology - 1 Jan 2010

Kariuki Silvia N, Franek Beverly S, Mikolaitis Rachel A, Utset Tammy O, Jolly Meenakshi, Skol Andrew D, Niewold Timothy B

Abstract excerpt

The PIK3C3 locus was implicated in case-case genome-wide association study of systemic lupus erythematosus (SLE) which we had performed to detect genes associated with autoantibodies and serum interferon-alpha (IFN-alpha). Herein, we examine a PIK3C3 promoter variant (rs3813065/-442 C/T) in an independent multiancestral cohort of 478 SLE cases and 522 controls. rs3813065 C was strongly associated with the...

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Source

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Identifiers

PMID: 20671926
DOI: 10.1155/2010/826434
PMCID: PMC2910508

Genes

ERAP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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