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Article

African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2010

Lodolce James P, Kolodziej Lauren E, Rhee Lesley, Kariuki Silvia N, Franek Beverly S, McGreal Nancy M, Logsdon Mark F, Bartulis Sarah J, Perera Minoli A, Ellis Nathan A, Adams Erin J, Hanauer Stephen B, Jolly Meenakshi, Niewold Timothy B, Boone David L

Abstract excerpt

The TNF alpha-induced protein 3 (TNFAIP3) is an ubiquitin-modifying enzyme and an essential negative regulator of inflammation. Genome-wide association studies have implicated the TNFAIP3 locus in susceptibility to autoimmune disorders in European cohorts, including rheumatoid arthritis, coronary artery disease, psoriasis, celiac disease, type 1 diabetes, inflammatory bowel disease, and systemic lupus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoblotting

Share to Immunoprecipitation

Share to Intracellular Signaling Peptides and Proteins

Share to Lupus Erythematosus, Systemic

Share to Protein Structure, Quaternary

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Open in PubMed Open full text

Identifiers

PMID: 20483768
DOI: 10.4049/jimmunol.1000324
PMCID: PMC3307531

Genes

TNFAIP3
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity.PMID 20483768Read ↗

Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune diseases.Semantic proximity Read ↗

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.Semantic proximity Read ↗

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.Semantic proximity Read ↗

The functional TNFAIP3 rs2230926T/G (Phe127Cys) variant confers risk to systemic lupus erythematosus in a Latin American population.Semantic proximity Read ↗

The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.Semantic proximity Read ↗

The association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.Semantic proximity Read ↗

TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development.Semantic proximity Read ↗

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.Semantic proximity Read ↗

Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus risk: an updated meta-analysis.Semantic proximity Read ↗

Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

A single-nucleotide polymorphism of the TNFAIP3 gene is associated with systemic lupus erythematosus in Chinese Han population.Semantic proximity Read ↗

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