Article
Genetic associations of LYN with systemic lupus erythematosus.
Genes and immunity - 1 Jul 2009
Lu R, Vidal G S, Kelly J A, Delgado-Vega A M, Howard X K, Macwana S R, Dominguez N, Klein W, Burrell C, Harley I T, Kaufman K M, Bruner G R, Moser K L, Gaffney P M, Gilkeson G S, Wakeland E K, Li Q-Z, Langefeld C D, Marion M C, Divers J, Alarcón G S, Brown E E, Kimberly R P, Edberg J C, Ramsey-Goldman R, Reveille J D, McGwin G, Vilá L M, Petri M A, Bae S-C, Cho S-K, Bang S-Y, Kim I, Choi C-B, Martin J, Vyse T J, Merrill J T, Harley J B, Alarcón-Riquelme M E, Nath S K, James J A, Guthridge J M
Abstract excerpt
We targeted LYN, a src-tyosine kinase involved in B-cell activation, in case-control association studies using populations of European-American, African-American and Korean subjects. Our combined European-derived population, consisting of 2463 independent cases and 3131 unrelated controls, shows significant association with rs6983130 in a female-only analysis with 2254 cases and 2228 controls (P=1.1 x 10(-4),...
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