Article
A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.
Nature genetics - 1 May 2005
Kochi Yuta, Yamada Ryo, Suzuki Akari, Harley John B, Shirasawa Senji, Sawada Tetsuji, Bae Sang-Cheol, Tokuhiro Shinya, Chang Xiaotian, Sekine Akihiro, Takahashi Atsushi, Tsunoda Tatsuhiko, Ohnishi Yozo, Kaufman Kenneth M, Kang Changsoo Paul, Kang Changwon, Otsubo Shigeru, Yumura Wako, Mimori Akio, Koike Takao, Nakamura Yusuke, Sasazuki Takehiko, Yamamoto Kazuhiko
Abstract excerpt
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-kappaB and regulates FCRL3 expression. We observed high FCRL3...
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