Article
Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups.
Arthritis and rheumatism - 1 Sept 2011
Tan Wenfeng, Sunahori Katsue, Zhao Jian, Deng Yun, Kaufman Kenneth M, Kelly Jennifer A, Langefeld Carl D, Williams Adrienne H, Comeau Mary E, Ziegler Julie T, Marion Miranda C, Bae Sang-Cheol, Lee Joo Hyun, Lee Ji-Seon, Chang Deh-Ming, Song Yeong Wook, Yu Chack-Yung, Kimberly Robert P, Edberg Jeffrey C, Brown Elizabeth E, Petri Michelle A, Ramsey-Goldman Rosalind, Vilá Luis M, Reveille John D, Alarcón-Riquelme Marta E, Harley John B, Boackle Susan A, Stevens Anne M, Scofield R Hal, Merrill Joan T, Freedman Barry I, Anaya Juan-Manuel, Criswell Lindsey A, Jacob Chaim O, Vyse Timothy J, Niewold Timothy B, Gaffney Patrick M, Moser Kathy L, Gilkeson Gary S, Kamen Diane L, James Judith A, Grossman Jennifer M, Hahn Bevra H, Tsokos George C, Tsao Betty P, Alarcón Graciela S
Abstract excerpt
OBJECTIVE: T cells from patients with systemic lupus erythematosus (SLE) express increased amounts of PP2Ac, which contributes to decreased production of interleukin-2 (IL-2). Because IL-2 is important in the regulation of several aspects of the immune response, it has been proposed that PP2Ac contributes to the expression of SLE. This study was designed to determine whether genetic variants of PPP2AC are linked...
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