Article
Accurate assembly of minority viral haplotypes from next-generation sequencing through efficient noise reduction.
Nucleic acids research - 27 Sept 2021
Knyazev Sergey, Tsyvina Viachaslau, Shankar Anupama, Melnyk Andrew, Artyomenko Alexander, Malygina Tatiana, Porozov Yuri B, Campbell Ellsworth M, Switzer William M, Skums Pavel, Mangul Serghei, Zelikovsky Alex
Abstract excerpt
Rapidly evolving RNA viruses continuously produce minority haplotypes that can become dominant if they are drug-resistant or can better evade the immune system. Therefore, early detection and identification of minority viral haplotypes may help to promptly adjust the patient's treatment plan preventing potential disease complications. Minority haplotypes can be identified using next-generation sequencing, but...
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