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Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data

1 Jan 2012

Abstract excerpt

Many viruses, including the clinically relevant RNA viruses HIV (human immunodeficiency virus) and HCV (hepatitis C virus), exist in large populations and display high genetic heterogeneity within and between infected hosts. Assessing intra-patient viral genetic diversity is essential for understanding the evolutionary dynamics of viruses, for designing effective vaccines, and for the success of antiviral...

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PMID: 22973268
DOI: 10.3389/fmicb.2012.00329

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