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Article

Viral population estimation using pyrosequencing.

PLoS computational biology - 9 May 2008

Eriksson Nicholas, Pachter Lior, Mitsuya Yumi, Rhee Soo-Yon, Wang Chunlin, Gharizadeh Baback, Ronaghi Mostafa, Shafer Robert W, Beerenwinkel Niko

Abstract excerpt

The diversity of virus populations within single infected hosts presents a major difficulty for the natural immune response as well as for vaccine design and antiviral drug therapy. Recently developed pyrophosphate-based sequencing technologies (pyrosequencing) can be used for quantifying this diversity by ultra-deep sequencing of virus samples. We present computational methods for the analysis of such sequence...

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Identifiers

PMID: 18437230
DOI: 10.1371/journal.pcbi.1000074
PMCID: PMC2323617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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