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Article

Differential transcriptional control of the H-2K and H-2D loci of the major histocompatibility complex in fibrosarcoma cells.

Immunological investigations - 1 Jan 2000

Aboud M, Amitai H, Huleihel M, Har-vardi I, Gopas J, Segal S

Abstract excerpt

In this study we demonstrate a differential transcription of H-2K and H-2D class-I genes in two different tumor cell clones; one is highly metastatic (IE-7) and the other is not metastatic (IC-9), both derived from the same fibrosarcoma, T-10, induced in an (H-2b x H-2k)F1 mouse. The expression of the two parental H-2K alleles is transcriptionally suppressed in both of these clones. In addition the IC-9 clone...

Topics

Alleles
Animals
Azacitidine
Clone Cells
Fibrosarcoma
Gene Expression Regulation
Gene Rearrangement
Genes, MHC Class I
H-2 Antigens
Interferon Type I
Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

RNA, Messenger

Suppression, Genetic

Transcription, Genetic

Source

Identifiers

PMID: 1724230
DOI: 10.3109/08820139109082628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1724230-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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