Polyoma tumorigenesis in mice: evidence for dominant resistance and dominant susceptibility genes of the host.

doi:10.1016/0042-6822(92)90248-n

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Article

Polyoma tumorigenesis in mice: evidence for dominant resistance and dominant susceptibility genes of the host.

Virology - 1 Dec 1992

Freund R, Dubensky T, Bronson R, Sotnikov A, Carroll J, Benjamin T

Abstract excerpt

We have determined the tumor responses of nine inbred mouse strains and of two F1 hybrids following inoculation with polyoma virus. The results showed wide variations in the frequencies of mice developing tumors. Correlation with H-2 haplotype were evident. C3H/BiDa mice of H-2k type were fully s...

Topics

Animals
Crosses, Genetic
Genes, Dominant
Genetic Variation
Haplotypes
Immunity, Innate
Mice
Mice, Inbred Strains
Neoplasms, Experimental
Polyomavirus
Tumor Virus Infections
Virulence

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