Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of the fibroblast growth factor receptor 4 expression and the G388R functional polymorphism on Cushing's disease outcome.

The Journal of clinical endocrinology and metabolism - 1 Oct 2010

Brito Luciana Pinto, Lerário Antonio Marcondes, Bronstein Marcello Delano, Soares Iberê Cauduro, Mendonca Berenice Bilharinho, Fragoso Maria Candida Barisson Villares

Abstract excerpt

CONTEXT: Abnormal FGFR4 expression has been detected in pituitary tumors, especially in larger and invasive adenomas. In addition, the FGFR4 functional polymorphism G388R has been associated with poor outcome in several human malignancies. Then, we hypothesized that FGFR4 expression and genotype could be markers of adverse outcome of Cushing's disease after transsphenoidal surgery. OBJECTIVES: The objective was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Arginine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Glycine

Share to Pituitary Neoplasms

Share to Receptor, Fibroblast Growth Factor, Type 4

Share to Recurrence

Share to Treatment Outcome

Source

Identifiers

PMID: 20660043
DOI: 10.1210/jc.2010-0047

Genes

FGFR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of the fibroblast growth factor receptor 4 expression and the G388R functional polymorphism on Cushing's disease outcome.PMID 20660043Read ↗

FGFR4 polymorphic variants modulate phenotypic features of Cushing disease.Semantic proximity Read ↗

Risk of recurrence after successful surgery for Cushing's disease and association with USP8 genotype and tumour size: an international, retrospective, longitudinal cohort study.Semantic proximity Read ↗

Evidence for orphan nuclear receptor TR4 in the etiology of Cushing diseaseSemantic proximity Read ↗

The USP8 Mutational Status in Combination With Postsurgical Cortisol Levels for Predicting Recurrence of Cushing Disease.Semantic proximity Read ↗

The fibroblast growth factor receptor 4 (FGFR4) Arg388 allele correlates with survival in head and neck squamous cell carcinoma.Semantic proximity Read ↗

A Polymorphism in the FGFR4 Gene Is Associated With Risk of Neuroblastoma and Altered Receptor Degradation.Semantic proximity Read ↗

N-myc downstream-regulated gene 2 (NDRG2) promoter methylation and expression in pituitary adenoma.Semantic proximity Read ↗

Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma.Semantic proximity Read ↗

A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours.Semantic proximity Read ↗

Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele.Semantic proximity Read ↗

Functional FGFR4 Gly388Arg polymorphism contributes to cancer susceptibility: Evidence from meta-analysis.Semantic proximity Read ↗

Do somatic USP8, USP48 and BRAF mutations differ in their genotype-phenotype correlation in Asian Indian patients with Cushing’s disease?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.