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Article

A Polymorphism in the FGFR4 Gene Is Associated With Risk of Neuroblastoma and Altered Receptor Degradation.

Journal of pediatric hematology/oncology - 1 Mar 2016

Whittle Sarah B, Reyes Sahily, Du Melissa, Gireud Monica, Zhang Linna, Woodfield Sarah E, Ittmann Michael, Scheurer Michael E, Bean Andrew J, Zage Peter E

Abstract excerpt

BACKGROUND: Outcomes for children with high-risk neuroblastoma are poor, and improved understanding of the mechanisms underlying neuroblastoma pathogenesis, recurrence, and treatment resistance will lead to improved outcomes. Aberrant growth factor receptor expression and receptor tyrosine kinase signaling are associated with the pathogenesis of many malignancies. A germline polymorphism in the FGFR4 gene is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26840079
DOI: 10.1097/MPH.0000000000000506
PMCID: PMC4758892

Genes

FGFR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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