Article
Risk of recurrence after successful surgery for Cushing's disease and association with USP8 genotype and tumour size: an international, retrospective, longitudinal cohort study.
The lancet. Diabetes & endocrinology - 1 Apr 2026
Zhang Qilin, Cai Yixin, Liu Yuyu, Yao Boyuan, Sharma Prajina, Ruoff Elisabeth, Ma Zengyi, Zopp Stephanie, Wu Yue, Abreu Ana Paula, Zhang Shuo, Tichomirowa Maria A, Wang Yi, Stalla Günter, Qiao Nidan, Ye Zhao, Hanzu Felicia A, Chen Hong, Buchfelder Michael, Yao Zhenwei, Flitsch Jörg, Li Yiming, Thorsteinsdottir Jun, Wang Yongfei, Nasi-Kordhishti Isabella, Ye Hongying, Honegger Jürgen, Sbiera Silviu, Kaiser Ursula B, Fassnacht Martin, Zhang Zhaoyun, Reincke Martin, Theodoropoulou Marily, Zhao Yao, Perez-Rivas Luis Gustavo
Abstract excerpt
BACKGROUND: Recurrence after successful pituitary surgery remains a challenge in the management of patients with Cushing's disease, with no reliable predictors of long-term outcome. Pathogenic somatic USP8 variants are found in one third of cases and their association with recurrence is unclear. The aim of this study was to determine the association between USP8 status and postoperative outcome. METHODS: This...
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