Article
FGFR4 polymorphic variants modulate phenotypic features of Cushing disease.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2014
Nakano-Tateno Tae, Tateno Toru, Hlaing Maw Maw, Zheng Lei, Yoshimoto Katsuhiko, Yamada Shozo, Asa Sylvia L, Ezzat Shereen
Abstract excerpt
Cushing disease is a potentially lethal condition resulting from hormone excess, usually due to a small pituitary tumor that fails to respond to negative feedback inhibition. A minority of patients develop larger, more aggressive tumors of the same lineage but with modest hormone excess. Here we show that a common polymorphism in the fibroblast growth factor receptor 4 (FGFR4) transmembrane domain yields receptor...
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