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Article

A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours.

Clinical endocrinology - 1 Jul 2024

Miao Hui, Wang Luo, Gong Fengying, Duan Lian, Wang Linjie, Yao Yong, Feng Ming, Deng Kan, Wang Renzhi, Xiao Yu, Ling Qing, Zhu Huijuan, Lu Lin

Abstract excerpt

OBJECTIVE: Somatic variants in the ubiquitin-specific protease 8 (USP8) gene are the most common genetic cause of Cushing disease. We aimed to explore the relationship between clinical outcomes and USP8 status in a single centre. DESIGN, PATIENTS AND MEASUREMENTS: We investigated the USP8 status in 48 patients with pituitary corticotroph tumours. A median of 62 months of follow-up was conducted after surgery from...

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PMID: 38691659
DOI: 10.1111/cen.15065

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