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Article

The USP8 Mutational Status in Combination With Postsurgical Cortisol Levels for Predicting Recurrence of Cushing Disease.

The Journal of clinical endocrinology and metabolism - 18 Dec 2025

Zhou Weiwei, Zheng Sichang, Ye Lei, Su Tingwei, Xie Jing, Jiang Lei, Jiang Yiran, Zhong Xu, Wu Luming, Zhou Wenzhong, Wang Weiqing

Abstract excerpt

CONTEXT: The ubiquitin-specific protease 8 (USP8) gene mutations are the most common driver changes in Cushing disease (CD). However, few studies have investigated the association between USP8 mutation and recurrence, and the results have been inconclusive. OBJECTIVE: To identify the predictors of recurrence and evaluate the prognostic role of USP8 mutation. METHODS: One hundred and seven patients with...

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Identifiers

PMID: 40424186
DOI: 10.1210/clinem/dgaf269

Genes

USP8
DST
MSC

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