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Article

Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease

7 May 2013

Abstract excerpt

Cushing disease (CD) is a life-threatening disorder attributed to excess pituitary tumor-derived adrenocorticotrophic hormone (ACTH) and adrenal steroid secretion caused by pituitary tumors. Whereas CD was first described in 1932, the underlying genetic basis driving tumor growth and ACTH secretion remains unsolved. Here, we show that testicular orphan nuclear receptor 4 (TR4, nuclear receptor subfamily 2, group...

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PMID: 23653479
DOI: 10.1073/pnas.1306182110

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