Article
Organic cation transporter 1 polymorphisms predict the metabolic response to metformin in women with the polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism - 1 Oct 2010
Gambineri Alessandra, Tomassoni Federica, Gasparini Daniela Ibarra, Di Rocco Antonio, Mantovani Vilma, Pagotto Uberto, Altieri Paola, Sanna Stefania, Fulghesu Anna Maria, Pasquali Renato
Abstract excerpt
CONTEXT: The determinants of the variability in the clinical response to metformin in women with the polycystic ovary syndrome (PCOS) are enigmatic. Organic cation transporter 1 (OCT1) plays a trigger role in the hepatic uptake of metformin. In cellular studies, it was recently shown that seven polymorphisms of OCT1 exhibit reduced transport of metformin. It is noteworthy that four of the seven variants, R61C...
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