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Article

Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.

The pharmacogenomics journal - 1 Dec 2011

Ahlin G, Chen L, Lazorova L, Chen Y, Ianculescu A G, Davis R L, Giacomini K M, Artursson P

Abstract excerpt

Common genetic variants of the liver-specific human organic cation transporter 1 (OCT1; SLC22A1) have reduced transport capacity for substrates such as the antidiabetic drug metformin. The effect of the reduced OCT1 function on drug interactions associated with OCT1 has not been investigated and...

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PMID: 20567254
DOI: 10.1038/tpj.2010.54

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20567254-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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