Article

Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control

2024-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Premature aging is a hallmark of Down syndrome, caused by trisomy of human chromosome 21, but the reason is unclear and difficult to study in humans. We used an aneuploid model in wild yeast to show that chromosome amplification disrupts nutrient-induced cell-cycle arrest, quiescence entry, and healthy aging, across genetic backgrounds and amplified chromosomes. We discovered that these defects...

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Literature Corpus work: beb39ade-0fa4-5dca-8def-b288905c1b7c
DOI: 10.1101/2024.06.22.600216

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