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Article

Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs.

Developmental biology - 15 Feb 2002

Johnson Ronald L, Zhou Lei, Bailey Evans C

Abstract excerpt

The membrane protein Patched (Ptc) is a critical regulator of Hedgehog signaling. Ptc is among a family of proteins that contain a sterol sensor motif. The function of this domain is poorly understood, but some proteins that contain sterol sensors are involved in cholesterol homeostasis. In the SREBP cleavage-activating protein (SCAP), sterols inhibit the protein's activity through this domain. Mutations in two...

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Source

Identifiers

PMID: 11820817
DOI: 10.1006/dbio.2001.0524

Genes

SCAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs.PMID 11820817Read ↗

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