Article

Sterols regulate ciliary membrane dynamics and hedgehog signaling in health and disease

2025-07-16

Abstract excerpt

The primary cilium is a specialized signaling hub whose function depends on a tightly regulated membrane composition. While its protein content is well-characterized, its lipid identity, particularly regarding sterols, remains poorly defined. Here, we used mass spectrometry-based lipidomics to map the sterol profile of isolated primary cilia from MDCK cells. We found that ciliary membranes are enriched in choleste...

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Identifiers and source

Literature Corpus work: 808ddc62-8968-5aac-a779-12f1986021a9
DOI: 10.1101/2025.07.15.664899

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