Article

Non-cell autonomous inhibition of the Hedgehog response due to impaired cholesterol synthesis requires Ptch1/2 function

2020-12-11

Abstract excerpt

Congenital birth defects due to mutations of enzymes involved cholesterol synthesis, like Smith-Lemli-Opitz syndrome (SLOS) and Lathosterolosis are characterized by an accumulation of cholesterol precursors. The phenotype of both SLOS and Lathosterolosis have similarities to syndromes associated with abnormal Sonic hedgehog (Shh) signaling, consistent with the observation that cholesterol precursors and their deri...

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Literature Corpus work: 99aabbb7-7adb-5ab8-b1ff-1d0da66f3d28
DOI: 10.1101/2020.12.10.420588

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