Article

Familial heterogeneity in breast cancer predisposition: a study of 22 Utah families

2016-12-09

Abstract excerpt

The problem of “missing heritability” in genome-wide analyses of complex diseases is thought to be attributable to some combination of: rare variants of moderate to large effect, common variants of very small effect, and epigenetic, epistatic, or shared environmental effects. Rare variants do not affect large numbers of people by definition, but identified genes and pathways frequently lead to important insights i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca60ba80-6bed-5a30-a67a-ac42f1c3aee0
DOI: 10.1101/092841

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Familial heterogeneity in breast cancer predisposition: a study of 22 Utah familiesDOI 10.1101/092841Read

Whole-genome Linkage Analysis and Sequence Analysis of Candidate Loci in Familial Breast Cancer.Semantic proximity Read

The impact of next generation sequencing on the analysis of breast cancer susceptibility: a role for extremely rare genetic variation?Semantic proximity Read

The genetics of breast cancer risk in the post-genome era: thoughts on study design to move past BRCA and towards clinical relevance.Semantic proximity Read

Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes.Semantic proximity Read

Segregation analysis of 17,425 population-based breast cancer families: evidence for genetic susceptibility and risk predictionSemantic proximity Read

Family Study Designs Informed by Tumor Heterogeneity and Multi-Cancer Pleiotropies: The Power of the Utah Population Database.Semantic proximity Read

Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities.Semantic proximity Read

Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer.Semantic proximity Read

Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers.Semantic proximity Read

Segregation analysis of 17,425 population-based breast cancer families: Evidence for genetic susceptibility and risk prediction.Semantic proximity Read

Breast cancer susceptibility: an integrative analysis of genomic dataSemantic proximity Read

A comprehensive examination of breast cancer risk loci in African American women.Semantic proximity Read