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Article

Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear family.

PLoS medicine - 1 Dec 2004

Amundadottir Laufey T, Thorvaldsson Sverrir, Gudbjartsson Daniel F, Sulem Patrick, Kristjansson Kristleifur, Arnason Sigurdur, Gulcher Jeffrey R, Bjornsson Johannes, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari

Abstract excerpt

BACKGROUND: The contribution of low-penetrant susceptibility variants to cancer is not clear. With the aim of searching for genetic factors that contribute to cancer at one or more sites in the body, we have analyzed familial aggregation of cancer in extended families based on all cancer cases diagnosed in Iceland over almost half a century. METHODS AND FINDINGS: We have estimated risk ratios (RRs) of cancer for...

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PMID: 15630470
DOI: 10.1371/journal.pmed.0010065
PMCID: PMC539051

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