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Article

p122 protein enhances intracellular calcium increase to acetylcholine: its possible role in the pathogenesis of coronary spastic angina.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2010

Murakami Reiichi, Osanai Tomohiro, Tomita Hirofumi, Sasaki Satoko, Maruyama Atsushi, Itoh Ken, Homma Yoshimi, Okumura Ken

Abstract excerpt

OBJECTIVE: Phospholipase C-δ1 activity is enhanced in patients with coronary artery spasm, and a p122 protein was recently cloned to potentiate phospholipase C-δ1 activity. To investigate the role of p122 in enhanced vasomotility, we examined p122 expression in the cultured skin fibroblasts obtained from patients with and without coronary spasm, intracellular Ca(2+) concentration ([Ca(2+)]i) [corrected] at...

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PMID: 20634475
DOI: 10.1161/ATVBAHA.110.203083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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