Article

The molecular mechanism of coronary spasm in iPSC-derived smooth muscle cells: Role of p122 RhoGAP/DLC-1 and phospholipase C-δ1

2022-08-03

Abstract excerpt

<h4>Background: </h4> We previously reported that the activity of phospholipase C-δ1 and the expression of p122RhoGTPase-activating protein (GAP)/deleted in liver cancer-1 (p122RhoGAP/DLC-1) were enhanced in skin fibroblasts obtained from patients with coronary spastic angina (CSA). Overexpression of p122RhoGAP/DLC-1 increased intracellular free calcium concentration ([Ca 2+ ] i ) in response to acetylcholine (ACh...

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Literature Corpus work: f54e97ee-6502-5b4f-a1a5-bfbd86aa7f58
DOI: 10.21203/rs.3.rs-1892138/v1

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