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Article

Coronary vasospasm induced in transgenic mouse with increased phospholipase C-δ1 activity.

Circulation - 28 Feb 2012

Shibutani Shuji, Osanai Tomohiro, Ashitate Toshihiro, Sagara Shigeki, Izumiyama Kei, Yamamoto Yuko, Hanada Kenji, Echizen Takashi, Tomita Hirofumi, Fujita Takeshi, Miwa Takeshi, Matsubara Hiroaki, Homma Yoshimi, Okumura Ken

Abstract excerpt

BACKGROUND: We reported that phospholipase C (PLC)-δ1 activity was enhanced 3-fold in patients with coronary spastic angina. We detected variant PLC-δ1 with replacement of arginine 257 by histidine (R257H) showing increased enzymatic activity. We tested the hypothesis that increased PLC-δ1 activi...

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PMID: 22265909
DOI: 10.1161/CIRCULATIONAHA.111.064303

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22265909-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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