Article
Mutation of ARHGAP9 in patients with coronary spastic angina.
Journal of human genetics - 1 Jan 2010
Takefuji Mikito, Asano Hiroyuki, Mori Kazutaka, Amano Mutsuki, Kato Katsuhiro, Watanabe Takashi, Morita Yasuhiro, Katsumi Akira, Itoh Toshiki, Takenawa Tadaomi, Hirashiki Akihiro, Izawa Hideo, Nagata Kozo, Hirayama Haruo, Takatsu Fumimaro, Naoe Tomoki, Yokota Mitsuhiro, Kaibuchi Kozo
Abstract excerpt
Coronary artery spasm has an important function in the etiology of variant angina and other acute coronary syndromes. Abnormal activation of Rho-family GTPases has been observed in cardiovascular disorders, but the function of genetic variability in Rho-family GTPases remains to be evaluated in cardiovascular disorders. We examined the genetic variability of Rho-family GTPases and their regulators in coronary...
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