Article
A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis.
Pharmacogenetics and genomics - 1 Nov 2007
Suzuki Satoru, Yoshimura Michihiro, Nakayama Masafumi, Abe Koji, Yamamuro Megumi, Nagayoshi Yasuhiro, Kojima Sunao, Kaikita Koichi, Sugiyama Seigo, Yasue Hirofumi, Ogawa Hisao
Abstract excerpt
OBJECTIVE: Coronary spasm plays an important role in the pathogenesis of variant angina and also ischemic heart diseases in general, and it is more likely to occur in angiographically normal coronary arteries than in stenotic coronary arteries. We previously found a -786T/C polymorphism in the 5'-flanking region of the endothelial nitric oxide synthase (eNOS) gene and reported that this polymorphism is associated...
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