Article
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.
Circulation - 5 May 2009
Yu Ying, Keller Steve H, Remillard Carmelle V, Safrina Olga, Nicholson Ann, Zhang Shenyuan L, Jiang Weihua, Vangala Nivruthi, Landsberg Judd W, Wang Jian-Ying, Thistlethwaite Patricia A, Channick Richard N, Robbins Ivan M, Loyd James E, Ghofrani Hossein A, Grimminger Friedrich, Schermuly Ralph T, Cahalan Michael D, Rubin Lewis J, Yuan Jason X-J
Abstract excerpt
BACKGROUND: Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role in the development of idiopathic pulmonary arterial hypertension (IPAH), whereas a rise in cytosolic Ca2+ concentration triggers PASMC contraction and stimulates PASMC proliferation. Recently, we demonstrated that upregulation of the TRPC6 channel contributes to proliferation of PASMCs isolated from IPAH...
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