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Article

Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm.

Pharmacogenetics - 1 Nov 2003

Nakayama Masafumi, Yoshimura Michihiro, Sakamoto Tomohiro, Shimasaki Yukio, Nakamura Shota, Ito Teruhiko, Abe Koji, Yamamuro Megumi, Miyamoto Yoshihiro, Saito Yoshihiko, Nakao Kazuwa, Yasue Hirofumi, Ogawa Hisao

Abstract excerpt

OBJECTIVE: We previously reported that a T-786-->C polymorphism in the 5'-flanking region of the endothelial nitric oxide synthase gene and smoking were independently associated with coronary spasm; however, the interaction between this polymorphism and smoking remains to be elucidated. METHODS: We analyzed 209 men and 238 women who were admitted consecutively at our institution; all subjects received an...

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PMID: 14583681
DOI: 10.1097/00008571-200311000-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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