Article
Impact of delta-sarcoglycan gene polymorphism on the occurrence of coronary spastic angina in Japanese patients with hypertrophic cardiomyopathy.
Circulation journal : official journal of the Japanese Circulation Society - 1 Aug 2007
Honda Tsuyoshi, Sugiyama Seigo, Sakamoto Tomohiro, Kaikita Koichi, Ogawa Hisao
Abstract excerpt
BACKGROUND: Patients with hypertrophic cardiomyopathy (HCM) frequently complain of angina-like symptoms in the absence of organic coronary stenoses. Coronary spasm might cause myocardial ischemia in HCM patients. Delta-sarcoglycan plays a crucial role in the pathogenesis of HCM and coronary spasm in a mouse model. METHODS AND RESULTS: This is a retrospective, single-center study with a small sample size. Seventy...
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