Article
Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Proceedings of the National Academy of Sciences of the United States of America - 25 May 2021
Katz Moshe, Subramaniam Suraj, Chomsky-Hecht Orna, Tsemakhovich Vladimir, Flockerzi Veit, Klussmann Enno, Hirsch Joel A, Weiss Sharon, Dascal Nathan
Abstract excerpt
L-type voltage-gated CaV1.2 channels crucially regulate cardiac muscle contraction. Activation of β-adrenergic receptors (β-AR) augments contraction via protein kinase A (PKA)-induced increase of calcium influx through CaV1.2 channels. To date, the full β-AR cascade has never been heterologously reconstituted. A recent study identified Rad, a CaV1.2 inhibitory protein, as essential for PKA regulation of CaV1.2....
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