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Article

Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases.

The Journal of general physiology - 1 Nov 2006

Seu Lillian, Pitt Geoffrey S

Abstract excerpt

Although inhibition of voltage-gated calcium channels by RGK GTPases (RGKs) represents an important mode of regulation to control Ca(2+) influx in excitable cells, their exact mechanism of inhibition remains controversial. This has prevented an understanding of how RGK regulation can be significant in a physiological context. Here we show that RGKs-Gem, Rem, and Rem2-decreased Ca(V)1.2 Ca(2+) current amplitude in...

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Identifiers

PMID: 17074979
DOI: 10.1085/jgp.200609631
PMCID: PMC2151584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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