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Article

Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor.

The Journal of physiology - 1 Sept 2013

Arnáiz-Cot Juan José, Damon Brooke James, Zhang Xiao-Hua, Cleemann Lars, Yamaguchi Naohiro, Meissner Gerhard, Morad Martin

Abstract excerpt

Cardiac ryanodine receptor (RyR2) is a homotetramer of 560 kDa polypeptides regulated by calmodulin (CaM), which decreases its open probability at diastolic and systolic Ca(2+) concentrations. Point mutations in the CaM-binding domain of RyR2 (W3587A/L3591D/F3603A, RyR2(ADA)) in mice result in severe cardiac hypertrophy, poor left ventricle contraction and death by postnatal day 16, suggesting that CaM inhibition...

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Identifiers

PMID: 23836685
DOI: 10.1113/jphysiol.2013.256123
PMCID: PMC3779117

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ADA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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