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Article

Enhancement of the recycling and activation of beta-adrenergic receptor by Rab4 GTPase in cardiac myocytes.

The Journal of biological chemistry - 21 Apr 2006

Filipeanu Catalin M, Zhou Fuguo, Lam May L, Kerut Kenneth E, Claycomb William C, Wu Guangyu

Abstract excerpt

We investigate the role of Rab4, a Ras-like small GTPase coordinating protein transport from the endosome to the plasma membrane, on the recycling and activation of endogenous beta-adrenergic receptor (beta-AR) in HL-1 cardiac myocytes in vitro and transgenic mouse hearts in vivo. Beta1-AR, the predominant subtype of beta-AR in HL-1 cardiac myocytes, was internalized after stimulation with isoproterenol (ISO) and...

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Identifiers

PMID: 16484224
DOI: 10.1074/jbc.M511460200
PMCID: PMC2735442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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