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Article

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

17 Nov 2003

Abstract excerpt

Rem, Rem2, Rad, and Gem/Kir (RGK) represent a distinct GTPase family with largely unknown physiological functions. We report here that both Rem and Rad bind directly to Ca2+ channel beta-subunits (CaV beta) in vivo. No calcium currents are recorded from human embryonic kidney 293 cells coexpressing the L type Ca2+ channel subunits CaV1.2, CaV beta 2a, and Rem or Rad, but CaV1.2 and CaV beta 2a transfected cells...

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Identifiers

PMID: 14623965
DOI: 10.1073/pnas.2437756100

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Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPasesPMID 14623965Read ↗

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