Article
Ca(2+) elevation evoked by membrane depolarization regulates G protein cycle via RGS proteins in the heart.
Circulation research - 23 Nov 2001
Ishii M, Inanobe A, Fujita S, Makino Y, Hosoya Y, Kurachi Y
Abstract excerpt
Regulators of G protein signaling (RGS), which act as GTPase activators, are a family of cytosolic proteins emerging rapidly as an important means of controlling G protein-mediated cell signals. The importance of RGS action has been verified in vitro for various kinds of cell function. Their in situ modes of action in intact cells are, however, poorly understood. Here we show that an increase in intracellular...
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