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Article

Functional assessment of three Rem residues identified as critical for interactions with Ca(2+) channel β subunits.

Pflugers Archiv : European journal of physiology - 1 Nov 2015

Beqollari Donald, Romberg Christin F, Filipova Dilyana, Papadopoulos Symeon, Bannister Roger A

Abstract excerpt

Members of the Rem, Rem2, Rad, Gem/Kir (RGK) family of small GTP-binding proteins inhibit high-voltage-activated (HVA) Ca(2+) channels through interactions with both the principal α1 and the auxiliary β subunits of the channel complex. Three highly conserved residues of Rem (R200, L227, and H229) have been shown in vitro to be critical for interactions with β subunits. However, the functional significance of...

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Identifiers

PMID: 25771954
DOI: 10.1007/s00424-015-1700-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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