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Article

Rad GTPase deletion increases L-type calcium channel current leading to increased cardiac contraction.

Journal of the American Heart Association - 12 Dec 2013

Manning Janet R, Yin Guo, Kaminski Catherine N, Magyar Janos, Feng Han-Zhong, Penn John, Sievert Gail, Thompson Katherine, Jin J-P, Andres Douglas A, Satin Jonathan

Abstract excerpt

BACKGROUND: The small GTPase Rad is a negative regulator of voltage-dependent L-type calcium channel current (ICaL); however, the effects of Rad ablation on cardiomyocyte function are unknown. The objective of this study is to test the hypothesis that Rad-depletion causes positive inotropic effects without inducing cardiac hypertrophy. METHODS AND RESULTS: Ventricular myocytes from adult Rad(-/-) mice were...

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Share to Adrenergic beta-Agonists
Share to Calcium-Calmodulin-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channels, L-Type

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Source

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Identifiers

PMID: 24334906
DOI: 10.1161/JAHA.113.000459
PMCID: PMC3886777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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