Article
Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Jul 2010
Decker Helena, Lo Karen Y, Unger Sandra M, Ferreira Sergio T, Silverman Michael A
Abstract excerpt
Disruption of axonal transport is a hallmark of several neurodegenerative diseases, including Alzheimer's disease (AD). Even though defective transport is considered an early pathologic event, the mechanisms by which neurodegenerative insults impact transport are poorly understood. We show that soluble oligomers of the amyloid-beta peptide (AbetaOs), increasingly recognized as the proximal neurotoxins in AD...
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