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Article

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons.

Acta neuropathologica communications - 21 Aug 2015

Umeda Tomohiro, Ramser Elisa M, Yamashita Minato, Nakajima Koichi, Mori Hiroshi, Silverman Michael A, Tomiyama Takami

Abstract excerpt

INTRODUCTION: Synaptic dysfunction and intracellular transport defects are early events in Alzheimer's disease (AD). Extracellular amyloid β (Aβ) oligomers cause spine alterations and impede the transport of proteins and organelles such as brain-derived neurotrophic factor (BDNF) and mitochondria that are required for synaptic function. Meanwhile, intraneuronal accumulation of Aβ precedes its extracellular...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26293809
DOI: 10.1186/s40478-015-0230-2
PMCID: PMC4546183

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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