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Article

Tau is essential to beta -amyloid-induced neurotoxicity.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Rapoport Mark, Dawson Hana N, Binder Lester I, Vitek Michael P, Ferreira Adriana

Abstract excerpt

Senile plaques and neurofibrillary tangles, the two hallmark lesions of Alzheimer's disease, are the results of the pathological deposition of proteins normally present throughout the brain. Senile plaques are extracellular deposits of fibrillar beta-amyloid peptide (Abeta); neurofibrillary tangles represent intracellular bundles of self-assembled hyperphosphorylated tau proteins. Although these two lesions are...

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Identifiers

PMID: 11959919
DOI: 10.1073/pnas.092136199
PMCID: PMC122954

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